Synthesis of 2-Alkylthioinosine 5'-Phosphates and N<SUP>2</SUP>-Methylated Guanosine 5'-Phosphates
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چکیده
منابع مشابه
Stereoselective synthesis of inositol phosphates
Pseudomonas putia'a oxidation of benzene affords cis-3,5-cyclohexadiene1,2diol (JJ which serves as a novel precursor for the syntheses of several natural products including (+)-pinitol, (+)-condunto1 F, D-(-)-myo-inositol 1,4,5-trisphosphate and Dmyo-inositol 1-phosphate. The versatility of this approach is further demonstrated by the preparation of other functionalised cyclitol derivatives, in...
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Modified nucleoside triphosphates (NTPs) represent powerful building blocks to generate nucleic acids with novel properties by enzymatic synthesis. We have recently demonstrated the access to 2'-SeCH(3)-uridine and 2'-SeCH(3)-cytidine derivatized RNAs for applications in RNA crystallography, using the corresponding nucleoside triphosphates and distinct mutants of T7 RNA polymerase. In the prese...
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7Jourdian, G. W., and S. Roseman, Abstracts, 137th Meeting of the American Chemical Society, 1960, p. 47C. 8 Byrne, W. L., and H. A. Lardy, Biochim. et Biophys. Acta, 14, 495-601 (1954). 9 Dische, Z., and Borenfreund, E., J. Biol. Chem., 180, 1297-1300 (1949). 10 Ballou, C. E., Arch. Biochem. & Biophys., 78, 328-333 (1958). 11 Warren, L., and H. Felsenfeld, Biochem. Biophys. Res. Comm., 4, 232-...
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Ribonucleoside 2',3'-cyclic phosphates (N>p's) are generated by multiple prebiotically plausible processes and are credible building blocks for the assembly of early RNA oligomers. While N>p's can be polymerized into short RNAs by non-enzymatic processes with variable efficiency and regioselectivity, no enzymatic route for RNA synthesis had been described. Here we report such a non-canonical 3'...
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An efficient synthesis of tri-, tetra-, and pentasaccharide cyclic phosphates 1-5, structurally related to natural inositol phosphate glycans, is reported. The title compounds were assembled by PhSeOTf-promoted glycosylation of the known glucosamine precursor, t-butyldimethylsilyl 2-azido-3,6-di-O-benzyl-2-deoxy-beta-D-glucopyranoside (8) with protected 1-methylthio mono-, di-, and trimannoside...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1968
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.16.338